The National Institutes of Health article called The Endocannabinoid System as an Emerging Target of Pharmacotherapy has positive findings regarding both the body's endocannabinoid system and, in some cases, the effects of cannabidiol in the treatment of seizures, cancer, liver disease (hepatitis and liver cirrhosis), muscular dystrophy, pain and inflammation, energy metabolism, multiple sclerosis, spinal cord injury, Lou Gehrig's disease (ALS), Gilles de la Tourette's syndrome (TS), tardive dyskinesia, and dystonia, Alzheimer's Disease, epilepsy, mental disorders including schizophrenia, insomnia, cardiovascular and respiratory disorders, hypertension, asthma, eye disorders (glaucoma and retinopathy), gastrointestinal and liver disorders, arthritis including rheumatoid arthritis, osteoporosis and reproduction, including erectile dysfunction.
The article states that "Among the 60 or so cannabinoids present in marijuana, only THC is psychoactive. However, some of the other constituents, such as cannabidiol, have well-documented biological effects of potential therapeutic interest, such as antianxiety, anticonvulsive, antinausea, anti-inflammatory and antitumor properties."
The article also cites that "The endocannabinoid system plays an important role in neuroprotection both in acute neuronal injury (e.g., traumatic brain injury, stroke, and epilepsy) and in chronic neurodegenerative disorders, such as multiple sclerosis, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease" (reviewed in Glass, 2001; Mechoulam et al., 2002a,b;Grundy, 2002; Croxford, 2003;Drysdale and Platt, 2003; Jackson et al., 2005a; Ramos et al., 2005).
The summary, in part, states: "The length of this review, necessitated by the steady growth in the number of indications for the potential therapeutic use of cannabinoid-related medications, is a clear sign of the emerging importance of this field. This is further underlined by the quantity of articles in the public database dealing with the biology of cannabinoids, which numbered ~200 to 300/year throughout the 1970s to reach an astonishing 5900 in 2004. The growing interest in the underlying science has been matched by a growth in the number of cannabinoid drugs in pharmaceutical development from two in 1995 to 27 in 2004, with the most actively pursued therapeutic targets being pain, obesity, and multiple sclerosis (Hensen, 2005)."
Pacher, P., Bátkai, S., & Kunos, G. (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacological reviews, 58(3), 389-462. doi:10.1124/pr.58.3.2
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